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Organ-On-Chip Global Market 2018 Including: Lung-On-Chip, Heart-On-Chip, Liver-On-Chip, Intestine-On-Chip, Kidney-On-Chip, Skin-On-Chip, Blood-Brain-Barrier-On-Chip And Human-On-Chip Covering: CN Bio Innovations, Emulate, TissUse, Mimetas, Hurel, Nortis, InSphero, Tara Biosystems, AxoSim Technologies, Organovo, Ascendence And HemoShear

Published on: Nov 2017 | From USD $4000 | Published By: THE BUSINESS RESEARCH COMPANY | Number Of Pages: 100

OOCs are microfluidic 3D cell culture devices that closely mimic the key physiological functions of body organs. These chips are not designed to biomimic an entire organ, but simulate the physiology of a single functional unit of an organ system.

These microchips are one of the most exciting areas of scientific research as they have the distinguishing characteristic of emulating the human micro environment in vitro. This unique feature of OOCs is made possible by integrating biology with advanced engineering technologies.

Scope of the Report This report covers OOCs manufactured by university spinoffs and others. It includes both organ models which are designed on typical chip-like structures and organ models which are designed on microfluidic micrometric plates.

Sections The report contains nine sections: Introduction, market characteristics, product analysis, market trends & models, market size, market drivers and restraints, funding landscape, competitor landscape, business model, customer analysis.

Introduction This section gives a general overview of OOCs which signifies their importance especially in the pharmaceutical industry.

Product Analysis This section gives an overview on the basic structure of an OOC and information on various techniques used for manufacturing these chips. Details about various organ specific models are also provided.

Market Characteristics and Trends This section covers the OOC market description at an overall level and trends that are shaping this industry.

Market Drivers and Restraints In this section analysis of the major factors that are driving the revenues of OOC and key limitations suppressing its market growth are discussed.

Market Size Analysis In this section we examine the global market size for OOC, both historic and forecast, followed by a regional split. Detailed information on the market size of OOC in the USA is provided, along with organ-level and end-user segmentation.

Funding Landscape This section covers information on the funds granted by government institutes or other organizations to either universities or companies for research and development of OOC devices.

Competitive Landscape This section considers key competitors in the OOC market along with the level of competition amongst them. Company profiles of key competitors and potential future players are provided, followed by information on average pricing of OOCs.

Business Model This section describes the business model of a typical OOC company.

Customer Analysis This section outlines the view of OOCs taken by current and potential end users, especially within the pharmaceutical industry. This is followed by information on current unmet needs in the OOC market.

Executive Summary of the report (If applicable)
Scientific advances in cell biology, microfabrication and microfluidics have led to the development of Organ-on-Chips (OOCs). OOCs are microfluidic 3D cell culture devices that closely mimic the key physiological functions of body organs. These chips are not designed to biomimic an entire organ, but simulate the physiology of a single functional unit of an organ system.

These microchips are one of the most exciting areas of scientific research as they have the distinguishing characteristic of emulating the human micro environment in vitro. This unique feature of OOCs is made possible by integrating biology with advanced engineering technologies.

OOC technology is still at an initial stage of research, development and commercialization. The players in the market are primarily university spinoffs involved in the commercialization of OOC prototypes developed in the universities. The key players include Emulate, CN-Bio Innovations, InSphero, Mimetas, TissUse, Hrel and Nortis. Currently OOCs are marketed primarily through sales agreements with end-users that involve collaboration of both parties in tailoring the OOCs to meet the end-users requirements.

The global market for OOCs was valued at $20 million in 2016. It is expected to grow at a compound annual growth rate (CAGR) of 70% to reach $284 million by 2021. The small size of the market is mainly due to the fact that OOCs have not yet been fully commercialized. They are still in the research and development phase and are primarily being used by a limited number of end-users. The OOC market is expected to rise at this high CAGR due to an increase in the number of collaborative sales agreements between the pharmaceutical companies and university spin-offs and the entry of new advanced models of OOCs into the market. The anticipated launch of advanced organ-specific models and human-on-chip models is expected to further increase the growth rate of this market in future.

Further improvements in the design and manufacture of OOCs will probably replace animal models as subjects in preclinical drug evaluations in future. Overall, they have the potential to break an impasse in in-vitro drug discovery and development.
Products Mentioned in the report (If applicable) -
Lung-on-chip, Heart-on-chip, Liver-on-chip, Intestine-on-chip, Kidney-on-chip and Human-on-chip Companies Mentioned in the report (If applicable)
CN Bio Innovations, Emulate Inc., TissUse GmbH, Mimetas, HREL Corporation (HREL), Nortis, InSphero, Tara Biosystems, AxoSim Techologies LLC, Organovo, Ascendance, and HemoShear

Executive Summary 7
Preface 8
Global Organ-On-Chip Market – Introduction 9
Organ-On-Chip Market Characteristics 11
Organ-On-Chip Origin And Significance 11
Organ-On-Chip Features 12
Organ-On-Chip Market – Product Analysis 13
Technical Description 13
Typical Organ-On-Chip Structure 13
Product Design Materials 14
Product Design Methodologies 14
Overview Of Organ-Specific Models 16
Lung-On-Chip 16
Heart-On-Chip 17
Liver-On-Chip 18
Intestine-On-Chip 19
Kidney-On-Chip 19
Skin-On-Chip 21
Blood-Brain-Barrier-On-Chip 22
Human-On-Chip 23
Organ-On-Chip Applications 24
Organ-On-Chip Commercialization 25
Organ-On-Chip Market Penetration 26
Price Information 26
Organ-On-Chip Market Trends and Models 27
Global Organ-On-Chip Market – Business Model 27
Five Force Analysis 30
Market Trends 31
Developments In The Testing Of Human Organs-On-Chip 31
Organ-On-Chip Technology In Space 31
Automated Monitoring Of Organ-On-Chips 31
3D Printing Of Organ-On Chips 31
Manufacturers Tying Up With End-users To Design Tailor-made Products 32
Investment In Integration Of Individual Organ-on-Chips Into Human-on-Chip 33
Strong Focus On Development of Custom Organ-On-Chips 33
Manufacturers Work On Disease Models To Expedite Drug Testing 33
Global Organ-On-Chip Market – Market Size Analysis 35
Market Sizing Methodology 35
Market Size Definition 35
Global Market For Organ-on-Chips 36
Global Market For Organ-On-Chips (Historic 2010-2016) 36
Global Market For Organ-On-Chips (Forecast 2016-2021) 37
Global Organ-On-Chip Market Segmentation By Organ Type 38
Global Organ-On-Chip Market Segmentation By Geography 41
North America 41
Europe 43
Asia 45
Rest of World (ROW) 47
Global Organ-On-Chip Market – Drivers And Restraints 49
Drivers 49
Government Funding Drives The Market For Organ-On-Chips 49
Improved Drug Screening With Organ-On-Chips Will Drive Demand 49
Drug Testing Cost Savings to Drive Demand For OOC 50
Ethical Concerns With Respect To Animal Models Will Drive The Organ-On-Chip Market 52
Restraints 53
Complex Manufacturing Techniques Are A Restraint On Organ-On-Chip Market Growth 53
Requirement For Specialized Equipment Will Be A Challenge For The Organ-On-Chip Market 53
Regulatory Hurdles For Drug Approvals 53
Global Organ-On-Chip Market – Funding Landscape 55
Funding Landscape – North America 55
Funding Landscape – Europe 58
Funding Landscape – Asia 59
Funding Landscape – ROW 59
Global Organ-On-Chip Market – Competitive Landscape 60
Key Players In The OOC Market 61
CN Bio Innovations 61
Emulate 63
TissUse 66
Mimetas 67
Hµrel 68
Nortis 70
Insphero 71
Tara Biosystems 72
AxoSim Technologies LLC 73
Organovo 74
Ascendance 75
HemoShear 76
Global Organ-On-Chip Market – Customer Analysis 77
Pharmaceuticals 77
Research Organizations 78
Consumer Goods and Cosmetics 78
Food and Beverages 79
Others 79
Global Organ-On-Chip Market – Conclusion 80
Strategies 81
Appendix 83
Interview Summaries 83
Interview Number 1 83
Interview Number 2 84
Interview Number 3 86
Interview Number 4 87
Interview Number 5 89
Interview Number 6 91
Interview Number 7 93
Abbreviations 95
Research Methodology 95
Currencies 96
Research Inquiries 96
The Business Research Company 96

List of Tables
Table 1: Global Organ-On-Chip Market, List Of Universities And Their Spinoffs 28
Table 2: Global Organ-On-Chip Market, Top Pharmaceutical Companies R&D Expenditures, 2015 and 2016, ($ billion) 50
Table 3: Global Organ-On-Chip Market, Institutions Funded By NIH, 2017 56
Table 4: Global Organ-On-Chip Market, Institutions Funded By NCATS For Tissue Chip Testing Centers, 2016 57
Table 5: Global Organ-On-Chip Market, Institutions Funded By NCATS, 2017 57
Table 6: Global Organ-On-Chip Market, CN Bio Collaborations With Pharmaceutical Companies 62
Table 7: Global Organ-On-Chip Market, CN Bio Collaborations With Academic Institutions 62
Table 8: Global Organ-On-Chip Market, HREL Products and its Description 68
Table 9: Global Organ-On-Chip Market, InSphero Products and its Description 71
Table 10: Global Organ-On-Chip Market, nSphero Collaborations With Academic Universities And Industries 72

List of Figures
Figure 1: Global Organ-On-Chip Market, Typical Organ-On-Chip Structure 13
Figure 2: Global Organ-On-Chip Market, Lung-On-Chip Model 16
Figure 3: Global Organ-On-Chip Market, Heart-On-Chip Model 17
Figure 4: Global Organ-On-Chip Market, Liver-On-Chip Model 18
Figure 5: Global Organ-On-Chip Market, Intestine-On-Chip Model 19
Figure 6: Global Organ-On-Chip Market, Kidney-On-Chip Model 20
Figure 7: Global Organ-On-Chip Market, Skin-On-Chip Model 21
Figure 8: Global Organ-On-Chip Market, Blood-Brain-Barrier-On-Chip Model 22
Figure 9: Global Organ-On-Chip Market, Human-On-Chip Model 23
Figure 10: Global Organ-On-Chip Market, Typical Business Model Of OOC Companies 27
Figure 11: Global Organ-On-Chip Market, Five Force Analysis 30
Figure 12: Global Organ-On-Chip Historic Market Size, 2010-2016, Value ($ million) 36
Figure 13: Global Organ-On-Chip Forecast Market Size, 2016-2021, Value ($ million) 37
Figure 14: Global Organ-On-Chip Market, Segmentation By Organ Type, 2016, (% share) 38
Figure 15: North America Organ-On-Chip Historic Market Size, 2010-2016, Value ($ million) 41
Figure 16: North America Organ-On-Chip Forecast Market Size, 2016-2021, Value ($ million) 42
Figure 17: Europe Organ-On-Chip Historic Market Size, 2010-2016, Value ($ million) 43
Figure 18: Europe Organ-On-Chip Forecast Market Size, 2016-2021, Value ($ million) 44
Figure 19: Asia Organ-On-Chip Historic Market Size, 2010-2016, Value ($ million) 45
Figure 20: Asia Organ-On-Chip Forecast Market Size, 2016-2021, Value ($ million) 46
Figure 21: ROW Organ-On-Chip Historic Market Size, 2010-2016, Value ($ million) 47
Figure 22: ROW Organ-On-Chip Forecast Market Size, 2016-2021, Value ($ million) 48
Figure 23: Global Organ-On-Chip Market, Predictability Scale Of Techniques In Drug Screening And Evaluation 50
Figure 24: Global Organ-On-Chip Market, Number Of New Drug Approvals By FDA And EMA, 2010-2016 51
Figure 25: Global Organ-On-Chip Market Funding Landscape Split By Regions, 2015-2017, Value, ($ million) 55
Figure 26: Global Organ-On-Chip Market Key Competitors Revenues, 2016 ($ million) 60
Figure 27: Global Organ-On-Chip Market Segmentation By End-Users, Value, 2016, ($ million) 77

SECONDARY RESEARCH
Secondary Research Information is collected from a number of publicly available as well as paid databases. Public sources involve publications by different associations and governments, annual reports and statements of companies, white papers and research publications by recognized industry experts and renowned academia etc. Paid data sources include third party authentic industry databases.

PRIMARY RESEARCH
Once data collection is done through secondary research, primary interviews are conducted with different stakeholders across the value chain like manufacturers, distributors, ingredient/input suppliers, end customers and other key opinion leaders of the industry. Primary research is used both to validate the data points obtained from secondary research and to fill in the data gaps after secondary research.

MARKET ENGINEERING
The market engineering phase involves analyzing the data collected, market breakdown and forecasting. Macroeconomic indicators and bottom-up and top-down approaches are used to arrive at a complete set of data points that give way to valuable qualitative and quantitative insights. Each data point is verified by the process of data triangulation to validate the numbers and arrive at close estimates.

EXPERT VALIDATION
The market engineered data is verified and validated by a number of experts, both in-house and external.

REPORT WRITING/ PRESENTATION
After the data is curated by the mentioned highly sophisticated process, the analysts begin to write the report. Garnering insights from data and forecasts, insights are drawn to visualize the entire ecosystem in a single report.

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